Reproductive Health Surveillance Program

The Reproductive Health Surveillance Program will continue and expand the work of the program established by Dr. Munson. The program is now led by Dr. Dalen Agnew, Michigan State University, and Dr. Anneke Moresco, Denver Zoo. Both trained with Dr. Munson, and know the program, the goals, and the database well, which has ensured a smooth transition and continuity. Additionally, both serve on the Reproductive Management Center's Advisory Board, ensuring close collaboration and communication regarding many RMC projects. For a list of studies by the RHSP, see here.

The RHSP conducts comprehensive pathologic examinations on reproductive tracts to detect deleterious effects associated with contraceptives. The results of these analyses are shared with the RMC and provide important information about contraceptive safety, infertility and subfertility that is incorporated in the Contraception Recommendations. Moving forward, these findings will also provide input for recommendations on reproduction and infertility cases. The data are also required for FDA reports. Complete reproductive tracts are needed from both contracepted and non-contracepted individuals of any age, male and female mammals, whether or not gross lesions are present (as many are microscopic), so that we can determine if diseases are spontaneous in a species or caused by the contraceptive. Tissue collected by ovariohysterectomy or castration or at necropsy are appropriate.

Tissue Submission Instructions

The archive and therefore the quality of the information we can provide heavily depends on your participation in submitting reproductive tracts. Because we are no longer able to provide reports free of charge, we have developed a flow chart to help you determine how best to participate.

  1. Option 1: Send whole tract to RHSP (address in submission form link below)
    1. No fee is charged, no pathology report is issued
    2. Please fill out the RHSP submission forms
    3. The reproductive tract is added to the RHSP archive
  2. Option 2: Send whole tract to Michigan State University DCPAH service, to share with RHSP
    1. A fee is charged and report is provided by DCPAH- MSU (see the above website or contact Dr. Dalen Agnew for current pricing)
    2. Please fill out the MSU and the RHSP submission forms
    3. Send to Dr. Dalen Agnew at the address below
    4. The reproductive tract is added to the RHSP archive
  3. Option 3: Share tissues with RHSP
    1. Send one tissue set to your pathologist, pay fee to him/her and receive report from him/ her
    2. Trim a separate set of samples for RHSP (half of each ovary, two section of each uterine horn, for more details see here)
    3. Send second set of tissues with RSHP submission form
    4. Processed as option 1 (no fee charged by RHSP, no report provided)
  4. Option 4: Share slides and / or report with RHSP
    1. Send tissues to your pathologist
    2. Pay him/ her and receive report from him/ her
    3. Request they send a recut of the reproductive tissue to RHSP (may add a small amount to your cost, probably comparable to shipping an extra set of tissues to RHSP)
    4. Fill out RHSP submission form, email form to amoresco@denverzoo.org
    5. Optional: forward a pathology report from your pathologist
 SHIPPING: Wrap fixed tracts in formalin-soaked paper towels, enclose in a leak-proof plastic container and ship by ground US mail (Federal Express is not necessary) to: 

Dr. Dalen Agnew
Attn: Histo Research
Diagnostic Center for Population and Animal Health
4125 Beaumont Rd.
Lansing, MI USA 48910-8104
Phone: 517-353-1683
agnewd@dcpah.msu.edu